LAMOTRIGINE (la MOE tri jeen) is used to control seizures in adults and children with epilepsy and Lennox-Gastaut syndrome. It is also used in adults to treat bipolar disorder.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

They need to know if you have any of these conditions: • heart disease • history of irregular heartbeat • immune system problems • kidney disease • liver disease • low levels of folic acid in the blood • lupus • mental illness • suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member • an unusual or allergic reaction to lamotrigine or other seizure medications, other medicines, foods, dyes, or preservatives • pregnant or trying to get pregnant • breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not chew these tablets. If this medicine upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medicine more often than directed. A special MedGuide will be given to you by the pharmacist with each new prescription and refill. Be sure to read this information carefully each time. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

-atazanavir • birth control pills • certain medicines for irregular heartbeat • certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, primidone, valproic acid • lopinavir • rifampin • ritonavir

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your doctor or health care providerfor regular checks on your progress. If you take this medicine for seizures, wear a Medic Alert bracelet or necklace. Carry an identification card with information about your condition, medicines, and doctor or health care provider. It is important to take this medicine exactly as directed. When first starting treatment, your dose will need to be adjusted slowly. It may take weeks or months before your dose is stable. You should contact your doctor or health care providerif your seizures get worse or if you have any new types of seizures. Do not stop taking this medicine unless instructed by your doctor or health care provider. Stopping your medicine suddenly can increase your seizures or their severity. This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms. You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can increase drowsiness and dizziness. Avoid alcoholic drinks. If you are taking this medicine for bipolar disorder, it is important to report any changes in your mood to your doctor or health care provider. If your condition gets worse, you get mentally depressed, feel very hyperactive or manic, have difficulty sleeping, or have thoughts of hurting yourself or committing suicide, you need to get help from your health care providerright away. If you are a caregiver for someone taking this medicine for bipolar disorder, you should also report these behavioral changes right away. The use of this medicine may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medicine. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe. Women who become pregnant while using this medicine may enroll in the North American Antiepileptic Drug Pregnancy Registry by calling 1-888-233-2334. This registry collects information about the safety of antiepileptic drug use during pregnancy. This medicine may cause a decrease in folic acid. You should make sure that you get enough folic acid while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care provider.

Keep out of the reach of children and pets. Store at 25 degrees C (77 degrees F). Protect from light. Get rid of any unused medicine after the expiration date. To get rid of medicines that are no longer needed or have expired: • Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location. • If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.