Even the largest and most in-depth studies have yet to prove a connection between vaccines and autism.
In 1998, former doctor Andrew Wakefield published a fraudulent study in The Lancet linking the measles, mumps and rubella (MMR) vaccine to autism. The study was widely discredited and retracted from publication, while Wakefield was barred from practicing medicine in the United Kingdom. Regardless, some still believe the connection.
In the years since, numerous studies from major organizations, including the World Health Organization, have shown that childhood vaccines are not harmful. Study after study has also shown that the MMR vaccine, in particular, does not cause autism in children who receive it.
In 2011, an Institute of Medicine (IOM) report, which examined eight vaccines given to both kids and adults, found that they are very safe. Then, in 2013, a CDC study examined the immune response to the vaccine in children during the first two years of life. They found no differences between kids with autism and those who did not have this condition.
More recently, a March 2019 study published in the Annals of Internal Medicine, analyzed the safety of the MMR vaccine even more rigorously. Researchers in Denmark used more children and more cases (hence more statistical power) to investigate concerns about a link between the vaccine and autism. They also included a larger number of children considered at high-risk for autism to address the specific claim that the MMR vaccines may be more dangerous for these kids.
The scientists evaluated whether the MMR vaccine increased the risk of autism in 657,461 children born in Denmark between 1999 and 2010. They tracked the kids until August 2013, documenting diagnoses of autism spectrum disorders and risk factors for these conditions, including parents’ ages, siblings with autism, method of delivery, smoking during pregnancy, preterm birth and low birth weight.
The study found no evidence of a link between the MMR vaccine and autism or an increased risk for these disorders—even among high-risk kids.
A February 2017 study published in Nature also suggests that the brain changes related to autism begin in early infancy, before a child would be given the MMR vaccine.
Nevertheless, with increased travel to places where the vaccine is not available—and more parents opting not to vaccinate their kids—the number of measles cases is on the rise.